Tumor Suppressors: Control of Signaling by Endocytosis

نویسندگان

  • Bernd Giebel
  • Andreas Wodarz
چکیده

Genetic defects of the endosomal 'ESCRT' machinery in Drosophila have been found to cause loss of epithelial cell polarity, accompanied by overproliferation of mutant and adjacent wild-type cells. These results can be attributed to defective endocytosis of transmembrane proteins that control cell polarity and proliferation, including Crumbs and Notch.

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عنوان ژورنال:
  • Current Biology

دوره 16  شماره 

صفحات  -

تاریخ انتشار 2006